Andrés Klein

Líneas de investigación

• Medicina de precisión en enfermedades lisosomales y Parkinson

Proyectos adjudicados

• UNRAVELING THE ROLE OF CELLULAR CLEARANCE IN GM2 GANGIOSIDOSIS (2016) Fuente: Cure and Action for Tay-Sachs (CATS) Foundation | Rol:
• IDENTIFICATION OF NOVEL GENES THAT MODIFY THE SEVERITY OF GAUCHER DISEASE (2014) Fuente: Rosetree of Trust, UK | Rol:
• LYSOMOD: GENETIC AND SMALL MOLECULE MODIFIERS OF LYSOSOMAL FUNCTION (2017) Fuente: Horizon 2020 Framework Programme(louvain;PT) | Rol:
• UNCOVERING THE GENETIC BASIS OF PHENOTYPIC HETEROGENEITY IN PARKINSON DISEASE (2018) Fuente: Pew Charitable Trusts(PA;PA;US) | Rol:
• UNCOVERING MODIFIER GENES OF LYSOSOMAL BIOLOGY BY EXPLOITING THE NATURAL GENETIC VARIATION OF INBRED MOUSE STRAINS (2018) Fuente: Fondo Nacional de Desarrollo Científico y Tecnológico(Santiago;CL) | Rol:

Tus publicaciones

• LACK OF ANNEXIN A6 EXACERBATES LIVER DYSFUNCTION AND REDUCES LIFESPAN OF NIEMANN-PICK TYPE C PROTEINDEFICIENT MICE Autores: Meneses-Salas; Elsa; Garcia-Forn; Marta; Castany-Pladevall; Carla; Lu; Albert; Fajardo; Alba; Jose; Jaimy; Wahba; Mohamed; Bosch; Marta; Pol; Albert; Tebar; Francesc; Klein; Andrés D.; Zanlungo; Silvana; Pérez-Navarro; Esther; Grewal; Thomas; Enrich; Carlos; Rentero; Carles Año: 2021 Link: https://doi.org/10.1016/j.ajpath.2020.12.009
• GENETIC BACKGROUND MATTERS: POPULATION-BASED STUDIES IN MODEL ORGANISMS FOR TRANSLATIONAL RESEARCH Autores: Valeria Olguín;Anyelo Durán;Macarena Las Heras;Juan Carlos Rubilar;Francisco A. Cubillos;Patricio Olguín;Andrés D. Klein; Año: 2022 Link: https://doi.org/10.3390/ijms23147570
• IDENTIFICATION OF GENETIC MODIFIERS OF MURINE HEPATIC -GLUCOCEREBROSIDASE ACTIVITY Año: 2021 Link: https://doi.org/10.1016/j.bbrep.2021.101105
• PROTEOMIC ANALYSIS OF NIEMANN-PICK TYPE C HEPATOCYTES REVEALS POTENTIAL THERAPEUTIC TARGETS FOR LIVER DAMAGE Autores: Elisa Balboa;Tamara Marín;Juan Esteban Oyarzún;Pablo S. Contreras;Robert Hardt;Thea van den Bosch;Alejandra R. Alvarez;Boris Rebolledo-Jaramillo;Andres D. Klein;Dominic Winter;Silvana Zanlungo; Año: 2021 Link: https://doi.org/10.3390/cells10082159
• C-ABL ACTIVATES RIPK3 SIGNALING IN GAUCHER DISEASE. Año: 2021 Link: https://doi.org/33549745
• LACK OF ANNEXIN A6 EXACERBATES LIVER DYSFUNCTION AND REDUCES LIFESPAN OF NPC1-DEFICIENT MICE Año: 2020 Link: https://doi.org/10.1016/j.ajpath.2020.12.009
• C-ABL INHIBITION ACTIVATES TFEB AND PROMOTES CELLULAR CLEARANCE IN A LYSOSOMAL DISORDER. Año: 2020 Link: https://doi.org/33163944
• NPC1 AS A MODULATOR OF DISEASE SEVERITY AND VIRAL ENTRY OF SARS-COV-2. Año: 2020 Link: https://doi.org/32660402
• FINDING PATHOGENIC COMMONALITIES BETWEEN NIEMANN-PICK TYPE C AND OTHER LYSOSOMAL STORAGE DISORDERS: OPPORTUNITIES FOR SHARED THERAPEUTIC INTERVENTIONS Año: 2020 Link: https://doi.org/10.1016/j.bbadis.2020.165875
• COMPLEMENT COMPONENT C3 PARTICIPATES IN EARLY STAGES OF NIEMANNPICK C MOUSE LIVER DAMAGE Autores: Andrés D. Klein;Javier González de la Vega;Silvana Zanlungo; Año: 2020 Link: https://doi.org/10.3390/ijms21062127
• INTEGRIN ALPHA E (CD103) LIMITS VIRUS-INDUCED IFN-I PRODUCTION IN CONVENTIONAL DENDRITIC CELLS. Año: 2020 Link: https://doi.org/33584680