Eduardo Fernando Ezquer Romero

Líneas de investigación

• Medicina Regenerativa para el tratamiento de la diabetes mellitus y sus complicaciones
• Medicina Regenerativa para el tratamiento de las adicciones

Proyectos adjudicados

• DEVELOPMENT OF NOVEL THERAPEUTIC ALTERNATIVES FOR ALCOHOL-USE DISORDERS: A MULTIDISCIPLINARY APPROACH (2021) Fuente: CONICYT | Rol:
• ACUTE ON CHRONIC LIVER FAILURE: REVERSION BY SYSTEMIC ADMINISTRATION OF 3D SPHEROIDS-DERIVED MESENCHYMAL STEM CELLS (2020) Fuente: CONICYT | Rol:
• OPIOID ADDICTION AND ASSOCIATED COGNITIVE DAMAGE: INHIBITION BY INTRANASAL MESENCHYMAL STEM CELL SECRETOME ADMINISTRATION (2020) Fuente: CONICYT | Rol:
• MESENCHYMAL STEM CELLS-SECRETOME PROVIDES PROTECTION IN NEONATAL HYPOXIA-REOXYGENATION. MECHANISMS AND TRANSLATIONAL STUDIES (2019) Fuente: FONDECYT (1190562) | Rol: COINVESTIGADOR(A)
• THE OXIDATIVE STRESS-NEUROINFLAMMATION SYNERGY=> ROLE IN THE PERPETUATION OF ALCOHOL INTAKE AND THERAPEUTIC AVENUES (2018) Fuente: FONDECYT (1180042) | Rol: COINVESTIGADOR(A)
• INTERNATIONAL RESEARCH NETWORK FOR THE DEVELOPMENT OF INDUCED PLURIPOTENT STEM CELL TECHNOLOGY (2017) Fuente: PCI (REDES15006) | Rol: COINVESTIGADOR(A)
• TREATING THE WHOLE NOT THE HOLE=> ADMINISTRATION OF ACELLULAR DERIVATIVE FROM MESENCHYMAL STEM CELLS SUBJECTED TO A PRECONDITIONING STIMULUS REVERTS DIABETIC NEUROPATHY AND PREVENTS DIABETIC FOOT ULCERS (2017) Fuente: FONDECYT (1170712) | Rol: INV. RESPONSABLE
• THE ETIOLOGY OF DIABETES AND/OR THE STAGE OF DIABETIC NEPHROPATHY MODIFY THE RENOPROTECTIVE EFFECT OF DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS? (2012) Fuente: FONDECYT (1120133) | Rol: COINVESTIGADOR(A)
• IDENTIFICATION OF CELLULAR AND MOLECULAR MECHANISMS BEHIND BETA-PANCREATIC ISLETS REGENERATION INDUCED BY MULTIPOTENT MESENCHYMAL STROMAL CELLS ADMINISTRATION INTO TYPE 1 DIABETIC MICE. (2008) Fuente: FONDECYT (11085033) | Rol: INV. RESPONSABLE
• IDENTIFICACION DE EPITOPES INMUNODOMINANTES INVOLUCRADOS EN LA RESPUESTA INMUNE CELULAR CONTRA HANTAVIRUS ANDES Y CARACTERIZACION DE LOS LINFOCITOS T RESPONSABLES=> BASE PARA EL DESARROLLO DE UNA VACUNA. (2005) Fuente: FONDECYT (1050667) | Rol: PERSONAL TÉCNICO Y/O DE APOYO
• GENETIC MECHANISMS OF AVERSION TO ETHANOL: CELLULAR AND MOLECULAR MODELS (2004) Fuente: FONDECYT(Santiago;CL) | Rol:
• IDENTIFICATION OF CELLULAR AND MOLECULAR MECHANISMS BEHIND BETA-PANCREATIC ISLETS REGENERATION INDUCED BY MULTIPOTENT MESENCHYMAL STROMAL CELLS IN TYPE 1 DIABETIC MICE (2009) Fuente: FONDECYT(Santiago;CL) | Rol:
• THE ETIOLOGY OF DIABETES AND/OR THE STAGE OF DIABETIC NEPHROPATHY MODIFY THE RENOPROTECTIVE EFFECT OF DONOR MULTIPOTENT MESENCHYMAL CELLS? (2012) Fuente: FONDECYT(Santiago;CL) | Rol:
• MESENCHYMAL STEM CELLS ACELLULAR PRODUCT PROMOTES REGENERATION OF LIVER STEATOSIS IN INDIVIDUALS UNDERGOING LIVER RESECTION SURGERY (2013) Fuente: FONDEF(Santiago;CL) | Rol:
• DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS MODIFY THE NATURAL EVOLUTION OF RETINAL DAMAGE IN DIABETIC MICE (2013) Fuente: FONDECYT(Santiago;CL) | Rol:
• EVALUATION OF THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELL -ACELULAR DERIVATE- ON DRUG INDUCED STEATOSIS IN A MODEL OF NORMAL AND IMPAIRED LIVER REGENERATION CAPACITY (2015) Fuente: FONDECYT(Santiago;CL) | Rol:

Tus publicaciones

• A DUAL MECHANISM FULLY BLOCKS ETHANOL RELAPSE: ROLE OF VAGAL INNERVATION Autores: Quintanilla; ME.; Ezquer; F.; Morales; P.; Santapau; D.; Ezquer; M.; Herrera-Marschitz; M.; Israel; Y. Año: 2022
• A DUAL TREATMENT BLOCKS ALCOHOL BINGE-DRINKING RELAPSE: MICROBIOTA AS A NEW PLAYER. Autores: Ezquer; F.; Quintanilla; ME.; Morales; P.; Santapau; D.; Munita; JM;; Moya-Flores; F.; Ezquer; M.; Herrera-Marschitz; M.; Israel; Y. Año: 2022
• A NOVEL MORPHINE DRINKING MODEL OF OPIOID DEPENDENCE IN RATS. Autores: Berríos-Cárcamo; P.; Quezada; M.; Santapau; D.; Morales; P.; Olivares; B.; Ponce; C.; Ávila; A.; De Gregorio; C.; Ezquer; M.; Quintanilla; ME.; Herrera-Marschitz; M.; Israel; Y.; Ezquer; F. Año: 2022
• SPATIAL MAPS AND OSCILLATIONS IN THE HEALTHY HIPPOCAMPUS OF OCTODON DEGUS A NATURAL MODEL OF SPORADIC ALZHEIMERS DISEASE Autores: Mugnaini; M.; Polania; D.; Diaz; Y.; Ezquer; M.; Ezquer; F.; Deacon; RMJ.; Cogram; P.; Kropff; E. Año: 2022
• ADMINISTRATION OF N-ACETYLCYSTEINE PLUS ACETYLSALICYLIC ACID MARKEDLY INHIBITS NICOTINE REINSTATEMENT FOLLOWING CHRONIC ORAL NICOTINE INTAKE IN FEMALE RATS Autores: Quintanilla; María Elena; Morales; Paola; Ezquer; Fernando; Ezquer; Marcelo; Herrera-Marschitz; Mario; Israel; Yedy Año: 2021 Link: https://doi.org/10.3389/fnbeh.2020.617418
• INNATE GUT MICROBIOTA PREDISPOSES TO HIGH ALCOHOL CONSUMPTION Autores: Ezquer; Fernando; Quintanilla; Maria Elena; Moya-Flores; Francisco; Morales; Paola; Munita; Jose Manuel; Olivares; Belen; Landskron; Glauben; Hermoso; Marcela A.; Ezquer; Marcelo; Herrera-Marschitz; Mario; Israel; Yedy Año: 2021
• NEONATAL MESENCHYMAL STEM CELL TREATMENT IMPROVES MYELINATION IMPAIRED BY GLOBAL PERINATAL ASPHYXIA IN RATS Autores: Tapia-Bustos; A.; Lespay-Rebolledo; C.; Vio; V.; Pérez-Loboz; R.; Casanova-Ortiz; E.; Ezquer; F.; Herrera-Marschitz; M.; Morales; P. Año: 2021
• CONTRIBUTION OF CONNEXIN HEMICHANNELS TO THE DECREASES IN CELL VIABILITY INDUCED BY LINOLEIC ACID IN THE HUMAN LENS EPITHELIAL CELLS HLE-B3 Autores: Figueroa V.A.; Jara O.; Oliva C.A.; Ezquer M.; Ezquer F.; Retamal M.A.; Martnez A.D.; Altenberg G.A.; Vargas A.A. Año: 2020 Link: https://doi.org/10.3389/fphys.2019.01574
• EXOSOMES RELEASED UPON MITOCHONDRIAL ASNCMTRNA KNOCKDOWN REDUCE TUMORIGENIC PROPERTIES OF MALIGNANT BREAST CANCER CELLS Autores: Lobos-Gonzlez L.; Bustos R.; Campos A.; Silva V.; Silva V.; Jeldes E.; Salomon C.; Varas-Godoy M.; Cceres-Verschae A.; Duran E.; Vera T.; Ezquer F.; Ezquer M.; Burzio; V.A.; Villegas J. Año: 2020
• HUMAN ADIPOSE-DERIVED MESENCHYMAL STEM CELL-CONDITIONED MEDIUM AMELIORATES POLYNEUROPATHY AND FOOT ULCERATION IN DIABETIC BKS DB/DB MICE Autores: De Gregorio; Cristian; Contador; David; Diaz; Diego; Carcamo; Constanza; Santapau; Daniela; Lobos-Gonzalez; Lorena; Acosta; Cristian; Campero; Mario; Carpio; Daniel; Gabriele; Caterina; Gaspari; Marco; Aliaga-Tobar; Victor; Maracaja-Coutinho; Vinicius; Ezquer; Marcelo; Ezquer; Fernando Año: 2020
• N-ACETYLCYSTEINE AND ACETYLSALICYLIC ACID INHIBIT ALCOHOL CONSUMPTION BY DIFFERENT MECHANISMS: COMBINED PROTECTION Autores: Quintanilla; Maria Elena; Ezquer; Fernando; Morales; Paola; Ezquer; Marcelo; Olivares; Belen; Santapau; Daniela; Herrera-Marschitz; Mario; Israel; Yedy. Año: 2020 Link: https://doi.org/10.3389/fnbeh.2020.00122
• SENSORY NEURON CULTURES DERIVED FROM ADULT DB/DB MICE AS A SIMPLIFIED MODEL TO STUDY TYPE-2 DIABETES-ASSOCIATED AXONAL REGENERATION DEFECTS Autores: De Gregorio; Cristian; Ezquer; Fernando Año: 2020 Link: https://doi.org/10.1242/dmm.046334
• ANTIOXIDANT BIOMOLECULES AND THEIR POTENTIAL FOR THE TREATMENT OF DIFFICULT-TO-TREAT DEPRESSION AND CONVENTIONAL TREATMENT-RESISTANT DEPRESSION Autores: María Eugenia Riveros;Alba Ávila;Koen Schruers;Fernando Ezquer; Año: 2022 Link: https://doi.org/10.3390/antiox11030540
• IMPROVING CELL RECOVERY: FREEZING AND THAWING OPTIMIZATION OF INDUCED PLURIPOTENT STEM CELLS Autores: Markus Uhrig;Fernando Ezquer;Marcelo Ezquer; Año: 2022 Link: https://doi.org/10.3390/cells11050799
• NEW PERSPECTIVES TO IMPROVE MESENCHYMAL STEM CELL THERAPIES FOR DRUG-INDUCED LIVER INJURY Autores: Fernando Ezquer;Ya-Lin Huang;Marcelo Ezquer; Año: 2022 Link: https://doi.org/10.3390/ijms23052669
• SUSTAINED ENERGY DEFICIT FOLLOWING PERINATAL ASPHYXIA: A SHIFT TOWARDS THE FRUCTOSE-26-BISPHOSPHATASE (TIGAR)-DEPENDENT PENTOSE PHOSPHATE PATHWAY AND POSTNATAL DEVELOPMENT Autores: Carolyne Lespay-Rebolledo;Andrea Tapia-Bustos;Ronald Perez-Lobos;Valentina Vio;Emmanuel Casanova-Ortiz;Nancy Farfan-Troncoso;Marta Zamorano-Cataldo;Martina Redel-Villarroel;Fernando Ezquer;Maria Elena Quintanilla;Yedy Israel;Paola Morales R;Mario Herrera-Marschitz; Año: 2021 Link: https://doi.org/10.3390/antiox11010074
• INTRANASAL ADMINISTRATION OF MESENCHYMAL STEM CELL SECRETOME REDUCES HIPPOCAMPAL OXIDATIVE STRESS NEUROINFLAMMATION AND CELL DEATH IMPROVING THE BEHAVIORAL OUTCOME FOLLOWING PERINATAL ASPHYXIA Autores: Nancy Farfán;Jaime Carril;Martina Redel;Marta Zamorano;Maureen Araya;Estephania Monzón;Raúl Alvarado;Norton Contreras;Andrea Tapia-Bustos;María Elena Quintanilla;Fernando Ezquer;José Luis Valdés;Yedy Israel;Mario Herrera-Marschitz;Paola Morales R; Año: 2020 Link: https://doi.org/10.3390/ijms21207800
• OXIDATIVE STRESS AND NEUROINFLAMMATION AS A PIVOT IN DRUG ABUSE. A FOCUS ON THE THERAPEUTIC POTENTIAL OF ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS AND BIOMOLECULES Autores: Pablo Berrios-Carcamo;Mauricio Quezada;María Elena Quintanilla;Paola Morales;Marcelo Ezquer;Mario Herrera-Marschitz;Yedy Israel;Fernando Ezquer; Año: 2020 Link: https://doi.org/10.3390/antiox9090830
• GENOME SEQUENCING VARIATIONS IN THE OCTODON DEGUS AN UNCONVENTIONAL NATURAL MODEL OF AGING AND ALZHEIMERS DISEASE Autores: Hurley, M.J.;Urra, C.;Garduno, B.M.;Bruno, A.;Kimbell, A.;Wilkinson, B.;Marino-Buslje, C.;Ezquer, M.;Ezquer, F.;Aburto, P.F.;Poulin, E.;Vasquez, R.A.;Deacon, R.;Avila, A.;Altimiras, F.;Whitney Vanderklish, P.;Zampieri, G.;Angione, C.;Constantino, G.;Holmes, T.C.;Coba, M.P.;Xu, X.;Cogram, P.; Año: 2022 Link: https://doi.org/10.3389/fnagi.2022.894994
• NEURONAL RUBICON REPRESSES EXTRACELLULAR APP/AMYLOID DEPOSITION IN ALZHEIMERS DISEASE Autores: Espinoza, S.;Grunenwald, F.;Gomez, W.;García, F.;Abarzúa-Catalan, L.;Oyarce-Pezoa, S.;Hernandez, M.F.;Cortés, B.I.;Uhrig, M.;Ponce, D.P.;Durán-Aniotz, C.;Hetz, C.;Sanmartín, C.D.;Cornejo, V.H.;Ezquer, F.;Parra, V.;Behrens, M.I.;Manque, P.A.;Rojas-Rivera, D.;Vidal, R.L.;Woehlbier, U.;Nassif, M.; Año: 2022 Link: https://doi.org/10.3390/cells11121860
• SCHIZOPHRENIA-DERIVED HIPSC BRAIN MICROVASCULAR ENDOTHELIAL-LIKE CELLS SHOW IMPAIRMENTS IN ANGIOGENESIS AND BLOODBRAIN BARRIER FUNCTION Autores: Casas, B.S.;Vitória, G.;Prieto, C.P.;Casas, M.;Chacón, C.;Uhrig, M.;Ezquer, F.;Ezquer, M.;Rehen, S.K.;Palma, V.; Año: 2022 Link: https://doi.org/10.1038/s41380-022-01653-0
• CORRIGENDUM TO: CONTRIBUTION OF CONNEXIN HEMICHANNELS TO THE DECREASES IN CELL VIABILITY INDUCED BY LINOLEIC ACID IN THE HUMAN LENS EPITHELIAL CELLS (HLE-B3) (FRONTIERS IN PHYSIOLOGY (2020) 10 10.3389/FPHYS.2019.01574) Autores: Figueroa, V.A.;Jara, O.;Oliva, C.A.;Ezquer, M.;Ezquer, F.;Retamal, M.A.;Martínez, A.D.;Altenberg, G.A.;Vargas, A.A.; Año: 2020 Link: https://doi.org/10.3389/fphys.2020.00072

Propiedad Intelectual

• Composición biofarmacológica que comprende componentes producidos y/o secretados por células troncales mesenquimales (MSC), que permite recuperar la capacidad regenerativa tisular, en una situación de esteatosis hepática, o donde la capacidad de regeneración endógena del tejido hepático se encuentra inhibida
• Composición inyectable o intranasal que comprende células madre mesenquimáticas (MSCs) sin estimular o precondicionadas, medios de cultivo derivados de MSCs precondicionadas o exosomas derivados de su cultivo, y excipientes; y su uso para reducir consumo de drogas o bloquear recaída por privación, en una persona con adicción