María Poli Harlowe

Líneas de investigación

• Respuesta Inmune en COVID 19
• Inmunodeficiencias Primarias y sindromes autoinflamatorios

Proyectos adjudicados

• MECANISMOS INMUNOLÓGICOS PROTECTORES Y BIOMARCADORES DE RESPUESTA INMUNE EN COVID19: IDENTIFICACIÓN DE DIANAS TERAPÉUTICAS PARA LA RECOMENDACIÓN DE TERAPIAS INMUNOMODULADORAS DE USO PRECOZ. (2020) Fuente: CONICYT | Rol:
• PRIMARY IMMUNODEFICIENCY (2018) Fuente: Jeffrey Modell Foundation (To Dr. Jordan Orange) | Rol: TESISTA
• IDENTIFICATION OF PRIMARY IMMUNODEFICIENCIES IN PATIENTS WITH PERSISTENT ASTHMA (2012) Fuente: LASID-Baxter Fellowship (no tiene) | Rol: INV. PRINCIPAL
• ESTUDIO DE FASE IV ABIERTO Y MULTICÉNTRICO PARA EVALUAR LA EFICACIA SEGURIDAD Y FARMACOCINÉTICA DE GAMMAPLEXR EN ENFERMEDADES DE INMUNODEFICIENCIA PRIMARIA EN NIÑOS Y ADOLESCENTES. (2011) Fuente: Gamaplex (GMX04) | Rol: COINVESTIGADOR(A)
• BIOMARKERS FOR IDENTIFICATION CHILEAN INFANTS AT RISK FOR RESPIRATORY SYNCYTIAL VIRUS RSV AND RHINOVIRUS RV- INDUCED SEVERE ACUTE LOWER RESPIRATORY INFECTION (2010) Fuente: FONDEF (1100477) | Rol: COINVESTIGADOR(A)
• EFECTOS DE CELECOXIB CELEBRA O NAPROXENO EN LA PRESIÓN SANGUÍNEA EN PACIENTES PEDIÁTRICOS CON ARTRITIS IDIOPÁTICA JUVENIL (2009) Fuente: Pfeizer | Rol: COINVESTIGADOR(A)
• DECIPHERING THE MECHANISMS OF DISEASE AND THERAPEUTIC TARGETS FOR PROTEASOME MATURATION PROTEIN (POMP)-RELATED AUTOINFLAMMATION AND IMMUNE DYSREGULATION (2018) Fuente: Fondo Nacional de Desarrollo Científico y Tecnológico(Santiago;Region Metropolitana;CL) | Rol:
• FUNCTIONAL GENOMICS IN AUTOINFLAMMATORY DISEASES (2022) Fuente: ANID(Santiago;Region Metropolitana;CL) | Rol:

Tus publicaciones

• THE 2021 EULAR AND ACR POINTS TO CONSIDER FOR DIAGNOSIS AND MANAGEMENT OF AUTOINFLAMMATORY TYPE I INTERFERONOPATHIES: CANDLE/PRAAS SAVI AND AGS Autores: Gedik; Kader Cetin; Lamot; Lovro; Romano; Micol; Demirkaya; Erkan; Piskin; David; Torreggiani; Sofia; Adang; Laura A.; Armangue; Thais; Barchus; Kathe; Cordova; Devon R.; Crow; Yanick J.; Dale; Russell C.; Durrant; Karen L.; Eleftheriou; Despina; Fazzi; Elisa M.; Gattorno; Marco; Gavazzi; Francesco; Hanson; Eric P.; Lee-Kirsch; Min Ae; Sanchez; Gina A. Montealegre; Neven; Benedicte; Orcesi; Simona; Ozen; Seza; Poli; M. Cecilia; Schumacher; Elliot; Tonduti; Davide; Uss; Katsiaryna; Aletaha; Daniel; Feldman; Brian M.; Vanderver; Adeline; Brogan; Paul A.; Goldbach-Mansky; Raphaela Año: 2022 Link: https://doi.org/10.1136/annrheumdis-2021-221814
• PARÁMETROS HEMATOLÓGICOS Y BIOMARCADORES PREDICTORES DE GRAVEDAD EN SÍNDROME INFLAMATORIO PEDIÁTRICO MULTISISTÉMICO ASOCIADO A SARS-COV-2 Autores: Verdugo; Patricia; Alvarez; Patricia; Montes; Vicente; Poli; M. Cecilia; Tapia; Lorena; Cofré; Fernanda; Soto; Verónica; Mackenney; Jorge; Carvajal; Cristián; Acevedo; Valeria Año: 2021 Link: https://doi.org/http://dx.doi.org/10.32641/andespediatr.v92i3.3316
• COMPROMISO CARDIOVASCULAR EN PACIENTES CON SÍNDROME INFLAMATORIO PEDIÁTRICO MULTISISTÉMICO ASOCIADO A INFECCIÓN POR SARS-COV-2 Autores: Álvarez; Patricia; Acevedo; Valeria; Valenzuela; María Lidia; Montes; Vicente; Aroca; Patricia; García; Carla; Campos; Carolina; Koch; Katherine; González; Soledad; Poli; Cecilia; Verdugo; Patricia; Cofré; Fernanda; Mackenney; Jorge; Tapia; Lorena Año: 2020 Link: https://doi.org/10.4067/S0718-85602020000300208
• ESPECTRO CLINICO DE LA INFECCION POR VIRUS SARS-CO-V2 EN UN CENTRO DE REFERENCIA PEDIÁTRICO EN PLENA PANDEMIA. REPORTE DEL COMITÉ CLÍNICO COVID HOSPITAL DE NIÑOS ROBERTO DEL RIO SANTIAGO CHILE Autores: Cofré; Fernanda; Mackenney; J.; Poli; M. Cecilia; Riquelme; Maryel; Carvajal; Cristian; Alvarez; Patricia; Acevedo; Valeria; Valenzuela; Lidia; Verdugo; Patricia; Varas; Mónica; Tapia; Lorena Año: 2020
• INMUNODEFICIENCIA COMBINADA SEVERA REPORTE DE PACIENTES CHILENOS DIAGNOSTICADOS DURANTE EL PERÍODO 1999-2020 Autores: Hoyos-Bachiloglu; Rodrigo; Rojas; Jorge; Borzutzky; Arturo; Hernández; Pamela; Vinet; Ana María; Bustos; Paula; Fernández; Fabiola; Lagos; Macarena; Strickler; Alexis; Marinovic; María Angélica; Casado; Cristina; Poli; María Cecilia; King; Alejandra Año: 2020 Link: https://doi.org/10.32641/rchped.v91i6.2580
• AUTOANTIBODIES AGAINST PROTEINS PREVIOUSLY ASSOCIATED WITH AUTOIMMUNITY IN ADULT AND PEDIATRIC PATIENTS WITH COVID-19 AND CHILDREN WITH MIS-C. Año: 2022 Link: https://doi.org/35360001
• GENETIC ERRORS OF IMMUNITY DISTINGUISH PEDIATRIC NONMALIGNANT LYMPHOPROLIFERATIVE DISORDERS Autores: Forbes, L.R.;Eckstein, O.S.;Gulati, N.;Peckham-Gregory, E.C.;Ozuah, N.W.;Lubega, J.;El-Mallawany, N.K.;Agrusa, J.E.;Poli, M.C.;Vogel, T.P.;Chaimowitz, N.S.;Rider, N.L.;Mace, E.M.;Orange, J.S.;Caldwell, J.W.;Aldave-Becerra, J.C.;Jolles, S.;Saettini, F.;Chong, H.J.;Stray-Pedersen, A.;Heslop, H.E.;Kamdar, K.Y.;Rouce, R.H.;Muzny, D.M.;Jhangiani, S.N.;Gibbs, R.A.;Coban-Akdemir, Z.H.;Lupski, J.R.;McClain, K.L.;Allen, C.E.;Chinn, I.K.; Año: 2022 Link: https://doi.org/10.1016/j.jaci.2021.07.015
• IMMUNOPATHOLOGICAL SIGNATURES IN MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN AND PEDIATRIC COVID-19 Autores: Sacco, K.;Castagnoli, R.;Vakkilainen, S.;Liu, C.;Delmonte, O.M.;Oguz, C.;Kaplan, I.M.;Alehashemi, S.;Burbelo, P.D.;Bhuyan, F.;de Jesus, A.A.;Dobbs, K.;Rosen, L.B.;Cheng, A.;Shaw, E.;Vakkilainen, M.S.;Pala, F.;Lack, J.;Zhang, Y.;Fink, D.L.;Oikonomou, V.;Snow, A.L.;Dalgard, C.L.;Chen, J.;Sellers, B.A.;Montealegre Sanchez, G.A.;Barron, K.;Rey-Jurado, E.;Vial, C.;Poli, M.C.;Licari, A.;Montagna, D.;Marseglia, G.L.;Licciardi, F.;Ramenghi, U.;Discepolo, V.;Lo Vecchio, A.;Guarino, A.;Eisenstein, E.M.;Imberti, L.;Sottini, A.;Biondi, A.;Mató, S.;Gerstbacher, D.;Truong, M.;Stack, M.A.;Magliocco, M.;Bosticardo, M.;Kawai, T.;Danielson, J.J.;Hulett, T.; Año: 2022 Link: https://doi.org/10.1038/s41591-022-01724-3
• PREVALENCE OF FILAGGRIN LOSS-OF-FUNCTION VARIANTS IN CHILEAN POPULATION WITH AND WITHOUT ATOPIC DERMATITIS Autores: Cárdenas, G.V.;Iturriaga, C.;Hernández, C.D.;Tejos-Bravo, M.;Pérez-Mateluna, G.;Cabalin, C.;Urzúa, M.;Venegas-Salas, L.F.;Fraga, J.P.;Rebolledo, B.;Poli, M.C.;Repetto, G.M.;Casanello, P.;Castro-Rodríguez, J.A.;Borzutzky, A.; Año: 2022 Link: https://doi.org/10.1111/ijd.15887
• PROTEIN KINASE R IS AN INNATE IMMUNE SENSOR OF PROTEOTOXIC STRESS VIA ACCUMULATION OF CYTOPLASMIC IL-24 Autores: Davidson, S.;Yu, C.-H.;Steiner, A.;Ebstein, F.;Baker, P.J.;Jarur-Chamy, V.;Schaale, K.H.;Laohamonthonkul, P.;Kong, K.;Calleja, D.J.;Harapas, C.R.;Balka, K.R.;Mitchell, J.;Jackson, J.T.;Geoghegan, N.D.;Moghaddas, F.;Rogers, K.L.;Mayer-Barber, K.D.;De Jesus, A.A.;De Nardo, D.;Kile, B.T.;Sadler, A.J.;Poli, M.C.;Krüger, E.;Mansky, R.G.;Masters, S.L.; Año: 2022 Link: https://doi.org/10.1126/sciimmunol.abi6763
• THE 2021 EURPEAN ALLIANCE OF ASSOCIATIONS FOR RHEUMATOLOGY/AMERICAN COLLEGE OF RHEUMATOLOGY POINTS TO CONSIDER FOR DIAGNOSIS AND MANAGEMENT OF AUTOINFLAMMATORY TYPE I INTERFERONOPATHIES: CANDLE/PRAAS SAVI AND AGS Autores: Cetin Gedik, K.;Lamot, L.;Romano, M.;Demirkaya, E.;Piskin, D.;Torreggiani, S.;Adang, L.A.;Armangue, T.;Barchus, K.;Cordova, D.R.;Crow, Y.J.;Dale, R.C.;Durrant, K.L.;Eleftheriou, D.;Fazzi, E.M.;Gattorno, M.;Gavazzi, F.;Hanson, E.P.;Lee-Kirsch, M.A.;Montealegre Sanchez, G.A.;Neven, B.;Orcesi, S.;Ozen, S.;Poli, M.C.;Schumacher, E.;Tonduti, D.;Uss, K.;Aletaha, D.;Feldman, B.M.;Vanderver, A.;Brogan, P.A.;Goldbach-Mansky, R.; Año: 2022 Link: https://doi.org/10.1136/annrheumdis-2021-221814
• [RECOMMENDATIONS FOR THE SUSPECTED DIAGNOSIS AND MANAGEMENT OF MULTISYSTEMIC INFLAMMATORY SYNDROME (MIS-C) IN THE CONTEXT OF A SARS-COV-2 PANDEMIC. APRIL 2021]. Año: 2021 Link: https://doi.org/34479294
• HEMATOLOGIC PARAMETERS AND BIOMARKERS PREDICTORS OF SEVERITY IN MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN ASSOCIATED WITH SARS-COV-2. Año: 2021 Link: https://doi.org/34479244
• FUNCTIONAL GENETICS IN INBORN ERRORS OF IMMUNITY Autores: Emma Rey-Jurado;María Cecilia Poli; Año: 2021 Link: https://doi.org/10.2217/frd-2020-0003
• CLINICAL NEUROIMAGING AND MOLECULAR SPECTRUM OF TECPR2-ASSOCIATED HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY WITH INTELLECTUAL DISABILITY. Año: 2021 Link: https://doi.org/33847017
• ABSENT B CELLS AGAMMAGLOBULINEMIA AND HYPERTROPHIC CARDIOMYOPATHY IN FOLLICULIN-INTERACTING PROTEIN 1 DEFICIENCY Autores: Francesco Saettini;Cecilia Poli;Jaime Vengoechea;Sonia Bonanomi;Julio C. Orellana;Grazia Fazio;Fred H. Rodriguez, III;Loreani P. Noguera;Claire Booth;Valentina Jarur-Chamy;Marissa Shams;Maria Iascone;Maja Vukic;Serena Gasperini;Manuel Quadri;Amairelys Barroeta Seijas;Elizabeth Rivers;Mario Mauri;Raffaele Badolato;Gianni Cazzaniga;Cristina Bugarin;Giuseppe Gaipa;Wilma G. M. Kroes;Daniele Moratto;Monique M. van Oostaijen-ten Dam;Frank Baas;Silvre van der Maarel;Rocco Piazza;Zeynep H. Coban-Akdemir;James R. Lupski;Bo Yuan;Ivan K. Chinn;Lucia Daxinger;Andrea Biondi; Año: 2021 Link: https://doi.org/10.1182/blood.2020006441
• CORONAVIRUS DISEASE 2019 IN PATIENTS WITH INBORN ERRORS OF IMMUNITY: AN INTERNATIONAL STUDY Autores: Meyts, I.;Bucciol, G.;Quinti, I.;Neven, B.;Fischer, A.;Seoane, E.;Lopez-Granados, E.;Gianelli, C.;Robles-Marhuenda, A.;Jeandel, P.-Y.;Paillard, C.;Sankaran, V.G.;Demirdag, Y.Y.;Lougaris, V.;Aiuti, A.;Plebani, A.;Milito, C.;Dalm, V.A.;Guevara-Hoyer, K.;Sánchez-Ramón, S.;Bezrodnik, L.;Barzaghi, F.;Gonzalez-Granado, L.I.;Hayman, G.R.;Uzel, G.;Mendona, L.O.;Agostini, C.;Spadaro, G.;Badolato, R.;Soresina, A.;Vermeulen, F.;Bosteels, C.;Lambrecht, B.N.;Keller, M.;Mustillo, P.J.;Abraham, R.S.;Gupta, S.;Ozen, A.;Karakoc-Aydiner, E.;Baris, S.;Freeman, A.F.;Yamazaki-Nakashimada, M.;Scheffler-Mendoza, S.;Espinosa-Padilla, S.;Gennery, A.R.;Jolles, S.;Espinosa, Y.;Poli, M.C.;Fieschi, C.;Hauck, F.;Cunningham-Rundles, C.; Año: 2021 Link: https://doi.org/10.1016/j.jaci.2020.09.010
• HSCT CORRECTS PRIMARY IMMUNODEFICIENCY AND IMMUNE DYSREGULATION IN PATIENTS WITH POMP-RELATED AUTOINFLAMMATORY DISEASE Autores: Martinez, C.;Ebstein, F.;Nicholas, S.K.;De Guzman, M.;Forbes, L.R.;Delmonte, O.M.;Bosticardo, M.;Castagnoli, R.;Krance, R.;Notarangelo, L.D.;Krüger, E.;Orange, J.S.;Poli, M.C.; Año: 2021 Link: https://doi.org/10.1182/blood.2021011005
• IMMUNE DYSREGULATION MIMICKING SYSTEMIC LUPUS ERYTHEMATOSUS IN A PATIENT WITH LYSINURIC PROTEIN INTOLERANCE: CASE REPORT AND REVIEW OF THE LITERATURE Autores: Contreras, J.L.;Ladino, M.A.;Aránguiz, K.;Mendez, G.P.;Coban-Akdemir, Z.;Yuan, B.;Gibbs, R.A.;Burrage, L.C.;Lupski, J.R.;Chinn, I.K.;Vogel, T.P.;Orange, J.S.;Poli, M.C.; Año: 2021 Link: https://doi.org/10.3389/fped.2021.673957
• MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN AND ADULTS (MIS-C/A): CASE DEFINITION & GUIDELINES FOR DATA COLLECTION ANALYSIS AND PRESENTATION OF IMMUNIZATION SAFETY DATA Autores: Vogel, T.P.;Top, K.A.;Karatzios, C.;Hilmers, D.C.;Tapia, L.I.;Moceri, P.;Giovannini-Chami, L.;Wood, N.;Chandler, R.E.;Klein, N.P.;Schlaudecker, E.P.;Poli, M.C.;Muscal, E.;Munoz, F.M.; Año: 2021 Link: https://doi.org/10.1016/j.vaccine.2021.01.054
• REFRACTORY SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS SUCCESSFULLY TREATED WITH RAPAMYCIN Autores: Concha, S.;Rey-Jurado, E.;Poli, M.C.;Hoyos-Bachiloglu, R.;Borzutzky, A.; Año: 2021 Link: https://doi.org/10.1093/rheumatology/keab114
• [CLINICAL MANIFESTATIONS OF SARS-COV-2 INFECTION IN CHILDREN IN THE MIDDLE OF PANDEMIC SEASON IN A PEDIATRIC TERTIARY CENTER. REPORT OF LOCAL COVID CLINICAL COMMITTEE HOSPITAL DE NIÑOS ROBERTO DEL RÍO SANTIAGO CHILE]. Año: 2020 Link: https://doi.org/33844817
• PEDIATRIC INFLAMMATORY MULTISYSTEM SYNDROME TEMPORALLY ASSOCIATED WITH SARS-COV-2 TREATED WITH TOCILIZUMAB Autores: Carmen Niño-Taravilla;Yazmín P. Espinosa-Vielma;H. Otaola-Arca, M.D., Ph.D.;Maria Cecilia Poli;Lorena I. Tapia;Paula Ortiz-Fritz; Año: 2020 Link: https://doi.org/10.3390/pediatric12030029
• [SEVERE COMBINED IMMUNODEFICIENCY REPORT OF CHILEAN PATIENTS DIAGNOSED DURING THE 1999-2020 PERIOD]. Año: 2020 Link: https://doi.org/33861827
• HEM1 DEFICIENCY DISRUPTS MTORC2 AND F-ACTIN CONTROL IN INHERITED IMMUNODYSREGULATORY DISEASE Autores: Sarah A. Cook;William A. Comrie;M. Cecilia Poli;Morgan Similuk;Andrew J. Oler;Aiman J. Faruqi;Douglas B. Kuhns;Sheng Yang;Alexander Vargas-Hernández;Alexandre F. Carisey;Benjamin Fournier;D. Eric Anderson;Susan Price;Margery Smelkinson;Wadih Abou Chahla;Lisa R. Forbes;Emily M. Mace;Tram N. Cao;Zeynep H. Coban-Akdemir;Shalini N. Jhangiani;Donna M. Muzny;Richard A. Gibbs;James R. Lupski;Jordan S. Orange;Geoffrey D. E. Cuvelier;Moza Al Hassani;Nawal Al Kaabi;Zain Al Yafei;Soma Jyonouchi;Nikita Raje;Jason W. Caldwell;Yanping Huang;Janis K. Burkhardt;Sylvain Latour;Baoyu Chen;Gehad ElGhazali;V. Koneti Rao;Ivan K. Chinn;Michael J. Lenardo; Año: 2020 Link: https://doi.org/10.1126/science.aay5663
• FIRST REPORT OF TOCILIZUMAB USE IN A COHORT OF LATIN AMERICAN PATIENTS HOSPITALIZED FOR SEVERE COVID-19 PNEUMONIA Autores: Valenzuela, O.;Ibáñez, S.;Poli, M.C.;Roessler, P.;Aylwin, M.;Roizen, G.;Iruretagoyena, M.;Agar, V.;Donoso, J.;Fierro, M.;Montes, J.; Año: 2020 Link: https://doi.org/10.3389/fmed.2020.596916
• SEVERE COMBINED IMMUNODEFICIENCY REPORT OF CHILEAN PATIENTS DIAGNOSED DURING THE 1999-2020 PERIODINMUNODEFICIENCIA COMBINADA SEVERA REPORTE DE PACIENTES CHILENOS DIAGNOSTICADOS DURANTE EL PERÍODO 1999-2020 Autores: Hoyos-Bachiloglu, R.;Rojas, J.;Borzutzky, A.;Hernández, P.;Vinet, A.M.;Bustos, P.;Fernández, F.;Lagos, M.;Strickler, A.;Marinovic, M.A.;Casado, C.;Poli, M.C.;King, A.; Año: 2020 Link: https://doi.org/10.32641/rchped.v91i6.2580
• PARTIAL LOSS-OF-FUNCTION MUTATIONS IN GINS4 LEAD TO NK CELL DEFICIENCY WITH NEUTROPENIA Autores: Matilde I. Conte;M. Cecilia Poli;Angelo Taglialatela;Giuseppe Leuzzi;Ivan K. Chinn;Sandra A. Salinas;Emma Rey-Jurado;Nixa Olivares;Liz Veramendi-Espinoza;Alberto Ciccia;James R. Lupski;Juan Carlos Aldave Becerra;Emily M. Mace;Jordan S. Orange; Año: 2022 Link: https://doi.org/10.1172/jci.insight.154948