Jaime Mella Raipan

Líneas de investigación

• Química Orgánica de Relación Estructura-Actividad: 2D-QSAR
• 3D-QSAR
• COMFA
• COMSIA
• Análisis de Hansch
• Docking

Tus publicaciones

• DESIGN SYNTHESIS IN SILICO STUDIES AND INHIBITORY ACTIVITY TOWARDS BCR-ABL BTK AND FLT3-ITD OF NEW 269-TRISUBSTITUTED PURINE DERIVATIVES AS POTENTIAL AGENTS FOR THE TREATMENT OF LEUKAEMIA Autores: Jeanluc Bertrand;Hana Dostálová;Vladimir Krystof;Radek Jorda;Thalía Delgado;Alejandro Castro-Alvarez;jaime mella;David Cabezas;Mario Faúndez;Christian Espinosa-Bustos;Cristian Salas; Año: 2022 Link: https://doi.org/10.3390/pharmaceutics14061294
• COUMARIN-RESVERATROL-INSPIRED HYBRIDS AS MONOAMINE OXIDASE B INHIBITORS: 3-PHENYLCOUMARIN VERSUS TRANS-6-STYRYLCOUMARIN Autores: Marco Mellado;César González;jaime mella;Luis Aguilar;ismail celik;Borges Fernanda;Eugenio Uriarte;Giovanna Delogu;Dolores Viña;Maria J. Matos; Año: 2022 Link: https://doi.org/10.3390/molecules27030928
• NOVEL N-ARYLSULFONYLINDOLES TARGETED AS LIGANDS OF THE 5-HT6 RECEPTOR. INSIGHTS ON THE INFLUENCE OF C-5 SUBSTITUTION ON LIGAND AFFINITY Autores: Loreto Arrieta-Rodríguez;Daniela Espinoza-Rosales;Gonzalo Vera;Young Hwa Cho;David Cabezas;David Vásquez Velásquez;jaime mella;Carlos F. Lagos;Gonzalo Recabarren; Año: 2021 Link: https://doi.org/10.3390/ph14060528
• SYNTHESIS DOCKING 3-D-QSAR AND BIOLOGICAL ASSAYS OF NOVEL INDOLE DERIVATIVES TARGETING SEROTONIN TRANSPORTER DOPAMINE D2 RECEPTOR AND MAO-A ENZYME: IN THE PURSUIT FOR POTENTIAL MULTITARGET DIRECTED LIGANDS Autores: Christopher Cerda-Cavieres;Gabriel Quiroz;Patricio Iturriaga-Vasquez;Julio Rodríguez-Lavado;Jazmín Alarcón-Espósito;Claudio Saitz;Carlos D. Pessoa-Mahana;Hery Chung;Ramiro Araya-Maturana;jaime mella;David Cabezas;Claudia Ojeda-Gómez;Miguel Reyes-Parada;Hernán Pessoa-Mahana; Año: 2020 Link: https://doi.org/10.3390/molecules25204614
• DESIGN SYNTHESIS AND MOLECULAR MODELING STUDIES OF A NOVEL BENZIMIDAZOLE AS AN AROMATASE INHIBITOR Autores: evik, U.A.;Celik, I.;Mella, J.;Mellado, M.;zkay, Y.;Kaplanclkll, Z.A.; Año: 2022 Link: https://doi.org/10.1021/acsomega.2c01497
• DEVELOPMENT OF 3D-QSAR AND PHARMACOPHORIC MODELS TO DESIGN NEW ANTI-TRYPANOSOMA CRUZI AGENTS BASED ON 2-ARYLOXYNAPHTHOQUINONE SCAFFOLD Autores: Paulino, M.;Espinosa-Bustos, C.;Bertrand, J.;Cabezas, D.;Mella, J.;Dávila, B.;Cerecetto, H.;Ballesteros-Casallas, A.;Salas, C.O.; Año: 2022 Link: https://doi.org/10.1080/1062936X.2022.2120069
• QSAR-DRIVEN SYNTHESIS OF ANTIPROLIFERATIVE CHALCONES AGAINST SH-SY5Y CANCER CELLS: DESIGN BIOLOGICAL EVALUATION AND REDESIGN Autores: Mellado, M.;Reyna-Jeldes, M.;Weinstein-Oppenheimer, C.;Covarrubias, A.A.;Aguilar, L.F.;Coddou, C.;Mella, J.;Cuellar, M.A.; Año: 2022 Link: https://doi.org/10.1002/ardp.202200042
• SYNTHESIS MOLECULAR MODELING 3D-QSAR AND BIOLOGICAL EVALUATION STUDIES OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENTIAL MAO-A AND MAO-B INHIBITORS Autores: Erol, M.;Celik, I.;Salk, B.N.;Karayel, A.;Mellado, M.;Mella, J.; Año: 2022 Link: https://doi.org/10.1016/j.molstruc.2022.133444
• COMBINED 3D-QSAR AND DOCKING ANALYSIS FOR THE DESIGN AND SYNTHESIS OF CHALCONES AS POTENT AND SELECTIVE MONOAMINE OXIDASE B INHIBITORS Autores: Mellado, M.;González, C.;Mella, J.;Aguilar, L.F.;Viña, D.;Uriarte, E.;Cuellar, M.;Matos, M.J.; Año: 2021 Link: https://doi.org/10.1016/j.bioorg.2021.104689
• DARK CLASSICS IN CHEMICAL NEUROSCIENCE: HEROIN AND DESOMORPHINE Autores: Mella-Raipán, J.;Romero-Parra, J.;Recabarren-Gajardo, G.; Año: 2020 Link: https://doi.org/10.1021/acschemneuro.0c00262
• 3-ARYLCOUMARINS AS HIGHLY POTENT AND SELECTIVE MONOAMINE OXIDASE B INHIBITORS: WHICH CHEMICAL FEATURES MATTER? Autores: Mellado; Marco; Mella; Jaime; Gonzalez; Cesar; Vina; Dolores; Uriarte; Eugenio; Matos; Maria J. Año: 2020 Link: https://doi.org/10.1016/j.bioorg.2020.103964
• NEW 269-TRISUBSTITUTED PURINE DERIVATIVES AS BCR-ABL AND BTK INHIBITORS AND AS PROMISING AGENTS AGAINST LEUKEMIA. Autores: Bertrand; J.; Dostalova; H.; Krystof; V.; Jorda; R.; Castro; A.; Mella; Jaime; Espinosa-Bustos; C.; Maria Zarate; A.; Salas; C. Año: 2020 Link: https://doi.org/10.1016/j.bioorg.2019.103361
• SYNTHESIS IN VITRO EVALUATION AND MOLECULAR DOCKING OF A NEW CLASS OF INDOLYLPROPYL BENZAMIDOPIPERAZINES AS DUAL ACHE AND SERT LIGANDS FOR ALZHEIMERS DISEASE Autores: Rodríguez-Lavado; Julio; Gallardo-Garrido C.; Mallea; M.; Bustos; V.; Osorio; R.; Hdar-Salazar; M.; Chung; H.; Araya-Maturana; R.; Lorca; M.; Pessoa-Mahana; C. D.; Mella-Raipán; Jaime; Saitz; C.; Jaque; P.; Reyes-Parada; M.; Iturriaga-Vásquez; P.; Pessoa-Mahana; H. Año: 2020 Link: https://doi.org/10.1016/j.ejmech.2020.112368