Camilo Ignacio López Alarcón

Proyectos adjudicados

• PRUEBA (2001) Fuente: Pontificia Universidad Católica de Chile(santiago;conicyt;CL) | Rol:
• OXIDATIVE MODIFICATIONS INDUCED BY CARBONATE RADICAL NITROGEN DIOXIDE AND PEROXYL RADICALS ON TWO ENZYMES OF THE PENTOSE PHOSPHATE PATHWAY: CONSEQUENCES ON NADPH RELEASE AND REDUCED GLUTATHIONE RECYCLING (2018) Fuente: CONICYT | Rol:
• PHOTOINDUCED FREE RADICALS AND EXCITED TRIPLET STATES FORMATION IN ORGANIZED BIOLOGICAL MIMETIC SYSTEMS. (2014) Fuente: FONDECYT (1140240) | Rol: COINVESTIGADOR(A)
• ROLE OF TRYTOPHAN RESIDUES IN THE AGGREGATION AND FRAGMENTATION OF PEPTIDES AND PROTEINS INDUCED BY PEROXYL AND CARBON-CENTERED RADICALS (2014) Fuente: FONDECYT (1141142) | Rol: INV. RESPONSABLE
• ADQUISICIÓN DE UN EQUIPO UHPLC-MS/MS PARA FORTALECER LA INVESTIGACIÓN INTERDISCIPLINARIA EN CIENCIAS QUÍMICAS Y FARMACÉUTICAS EN LA FACULTAD DE QUÍMICA DE LA PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. (2013) Fuente: FONDEQUIP (EQM130032) | Rol: DIRECTOR(A)
• ESTUDIO DEL DAÑO OXIDATIVO SOBRE PROTEÍNAS MIOFIBRILARES MEDIADO POR RADICALES PEROXILO HIDROSOLUBLES=> ROL DE POLIFENOLES OBTENIDOS DE PIEL Y SEMILLA DE MANGO MANGIFERA INDICA L. COMO POTENCIALES COMPUESTOS ANTIOXIDANTES (2013) Fuente: FONDECYT (3140307) | Rol: INV. PATROCINANTE
• REACTIVITY OF ANTIOXIDANTS TOWARD NITROXIDES AND PHOTOINDUCED FREE RADICALS IN COMPARTMENTALIZED SYSTEMS. (2011) Fuente: FONDECYT (1110809) | Rol: COINVESTIGADOR(A)
• EXTENDING THE USE OF PYROGALLOL RED AS PROBE IN METHODOLOGIES AIMED TO ESTIMATE THE SCAVENGING ACTIVITY OF BEVERAGES AND FOODS TOWARDS NITRITE HYPOCHLOROUS ACID CHLORAMINES AND PEROXYL RADICALS. (2009) Fuente: FONDECYT (1100659) | Rol: INV. RESPONSABLE
• NITROXIDES PREFLUORESCENT PROBLES ON THE FREE RADICAL MONITORING IN PROTEINS MONOLAYERS AND CELLS (2008) Fuente: FONDECYT (1085177) | Rol: COINVESTIGADOR(A)
• DESARROLLO Y APLICACION DE NUEVOS METODOS PARA EVALUAR CAPACIDAD ANTIOXIDANTE EN MEDIO ACUOSO MEDIO ORGANICO Y MICELAS. (2006) Fuente: FONDECYT (11060323) | Rol: INV. RESPONSABLE
• ESTUDIO CINETICO DE LA REACTIVIDAD SECUNDARIA DE FLAVONOIDES FENOLES Y POLIFENOLES RELACIONADOS (2004) Fuente: FONDECYT (3040002) | Rol: INV. RESPONSABLE
• SINTESIS Y CARACTERIZACION ELECTROQUIMICA DE 1.4-DIHIDROPIRIDINAS-4-SUSTITUIDAS. (2001) Fuente: FONDECYT (2010044) | Rol: INV. RESPONSABLE
• ADQUISICION DE UN EQUIPO UHPLC-MS/MS PARA FORTALECER LA INVESTIGACION INTERDISCIPLINARIA EN CIENCIAS QUIMICAS Y FARMACEUTICAS EN LA FACULTAD DE QUIMICA DE LA PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. (2013) Fuente: FONDEQUIP (EQM130032) | Rol: DIRECTOR(A)
• ESTUDIO DEL DANO OXIDATIVO SOBRE PROTEINAS MIOFIBRILARES MEDIADO POR RADICALES PEROXILO HIDROSOLUBLES=> ROL DE POLIFENOLES OBTENIDOS DE PIEL Y SEMILLA DE MANGO MANGIFERA INDICA L. COMO POTENCIALES COMPUESTOS ANTIOXIDANTES (2013) Fuente: FONDECYT (3140307) | Rol: INV. PATROCINANTE

Tus publicaciones

• PEROXYL RADICALS MODIFY 6-PHOSPHOGLUCONOLACTONASE FROM ESCHERICHIA COLI VIA OXIDATION OF SPECIFIC AMINO ACIDS AND AGGREGATION WHICH INHIBITS ENZYME ACTIVITY Autores: Juan Sebastián Reyes;Eduardo Fuentes-Lemus;Jefferson Romero;Felipe Arenas;Angélica Fierro;Michael J. Davies;Camilo López-Alarcón; Año: 2023 Link: https://doi.org/10.1016/j.freeradbiomed.2023.04.019
• ROLE OF AMINO ACID OXIDATION AND PROTEIN UNFOLDING IN PEROXYL RADICAL AND PEROXYNITRITE-INDUCED INACTIVATION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES Autores: Juan David Figueroa;Eduardo Fuentes-Lemus;Juan Sebastián Reyes;Matías Loaiza;Margarita E. Aliaga;Angélica Fierro;Fabian Leinisch;Per Hgglund;Michael J. Davies;Camilo López-Alarcón; Año: 2022 Link: https://doi.org/10.1016/j.freeradbiomed.2022.08.010
• CROWDING MODULATES THE GLYCATION OF PLASMA PROTEINS: IN VITRO ANALYSIS OF STRUCTURAL MODIFICATIONS TO ALBUMIN AND TRANSFERRIN AND IDENTIFICATION OF SITES OF MODIFICATION Autores: Fuentes-Lemus, E.;Reyes, J.S.;López-Alarcón, C.;Davies, M.J.; Año: 2022 Link: https://doi.org/10.1016/j.freeradbiomed.2022.10.319
• IMPLICATIONS OF DIFFERENTIAL PEROXYL RADICAL-INDUCED INACTIVATION OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE AND 6-PHOSPHOGLUCONATE DEHYDROGENASE FOR THE PENTOSE PHOSPHATE PATHWAY Autores: Reyes, J.S.;Fuentes-Lemus, E.;Figueroa, J.D.;Rojas, J.;Fierro, A.;Arenas, F.;Hgglund, P.M.;Davies, M.J.;López-Alarcón, C.; Año: 2022 Link: https://doi.org/10.1038/s41598-022-25474-x
• OXIDATIVE CROSSLINKING OF PEPTIDES AND PROTEINS: MECHANISMS OF FORMATION DETECTION CHARACTERIZATION AND QUANTIFICATION Autores: Fuentes-Lemus, E.;Hgglund, P.;López-Alarcón, C.;Davies, M.J.; Año: 2022 Link: https://doi.org/10.3390/molecules27010015
• OXIDATION OF LYSOZYME INDUCED BY PEROXYL RADICALS INVOLVES AMINO ACID MODIFICATIONS LOSS OF ACTIVITY AND FORMATION OF SPECIFIC CROSSLINKS Autores: Fuentes-Lemus; Eduardo; Mariotti; Michele; Hgglund; Per; Leinisch; Fabian; Fierro Angélica; Silva; Eduardo; Davies; Michael J.; Lopez-Alarcon; Camilo Año: 2021 Link: https://doi.org/DOI: 10.1016/j.freeradbiomed.2021.03.009
• EFFECT OF MACROMOLECULAR CROWDING ON PROTEIN OXIDATION: CONSEQUENCES ON THE RATE EXTENT AND OXIDATION PATHWAYS Autores: Fuentes-Lemus, E.;Reyes, J.S.;Gamon, L.F.;López-Alarcón, C.;Davies, M.J.; Año: 2021 Link: https://doi.org/10.1016/j.redox.2021.102202
• M. JANNASCHII FTSZ A KEY PROTEIN IN BACTERIAL CELL DIVISION IS INACTIVATED BY PEROXYL RADICAL-MEDIATED METHIONINE OXIDATION Autores: Reyes; Juan Sebastian; Fuentes-Lemus; Eduardo; Aspee; Alexis; Davies; Michael J.; Monasterio; Octavio; Lopez-Alarcon; Camilo Año: 2021 Link: https://doi.org/10.1016/j.freeradbiomed.2021.02.003
• PHOTO-INDUCED PROTEIN OXIDATION: MECHANISMS CONSEQUENCES AND MEDICAL APPLICATIONS Autores: Fuentes-Lemus; Eduardo; Lopez-Alarcon; Camilo; Hooper; N Año: 2020 Link: https://doi.org/10.1042/EBC20190044
• AZOCOMPOUNDS AS GENERATORS OF DEFINED RADICAL SPECIES: CONTRIBUTIONS AND CHALLENGES FOR FREE RADICAL RESEARCH Autores: Lopez-Alarcon; Camilo; Fuentes-Lemus; Eduardo; Figueroa; Juan David; Dorta; Eva; Schoeneich; Christian; Davies; Michael J. Año: 2020 Link: https://doi.org/10.1016/j.freeradbiomed.2020.06.021
• FORMATION AND CHARACTERIZATION OF CROSSLINKS INCLUDING TYRTRP SPECIES ON ONE ELECTRON OXIDATION OF FREE TYR AND TRP RESIDUES BY CARBONATE RADICAL ANION Autores: Juan David Figueroa;Ana María Zárate;Eduardo Fuentes-Lemus;Michael J. Davies;Camilo López-Alarcón; Año: 2020 Link: https://doi.org/10.1039/D0RA04051G
• FREE RADICALS DERIVED FROM -RADIOLYSIS OF WATER AND AAPH THERMOLYSIS MEDIATE OXIDATIVE CROSSLINKING OF EGFP INVOLVING TYR-TYR AND TYR-CYS BONDS: THE FLUORESCENCE OF THE PROTEIN IS CONSERVED ONLY TOWARDS PEROXYL RADICALS Autores: Zamora, R.A.;Fuentes-Lemus, E.;Barrias, P.;Herrera-Morande, A.;Mura, F.;Guixé, V.;Castro-Fernandez, V.;Rojas, T.;López-Alarcón, C.;Aguirre, P.;Rivas-Aravena, A.;Aspée, A.; Año: 2020 Link: https://doi.org/10.1016/j.freeradbiomed.2020.02.006
• PHOTO-OXIDATION OF LYSOZYME TRIGGERED BY RIBOFLAVIN IS O2-DEPENDENT OCCURS VIA MIXED TYPE 1 AND TYPE 2 PATHWAYS AND RESULTS IN INACTIVATION SITE-SPECIFIC DAMAGE AND INTRA- AND INTER-MOLECULAR CROSSLINKS Autores: Fuentes-Lemus, E.;Mariotti, M.;Reyes, J.;Leinisch, F.;Hgglund, P.;Silva, E.;Davies, M.J.;López-Alarcón, C.; Año: 2020 Link: https://doi.org/10.1016/j.freeradbiomed.2020.03.004
• PROTEIN QUANTIFICATION BY BICINCHONINIC ACID (BCA) ASSAY FOLLOWS COMPLEX KINETICS AND CAN BE PERFORMED AT SHORT INCUBATION TIMES Autores: Cortés-Ríos, J.;Zárate, A.M.;Figueroa, J.D.;Medina, J.;Fuentes-Lemus, E.;Rodríguez-Fernández, M.;Aliaga, M.;López-Alarcón, C.; Año: 2020 Link: https://doi.org/10.1016/j.ab.2020.113904
• PHOTO-OXIDATION OF LYSOZYME TRIGGERED BY RIBOFLAVIN IS O2-DEPENDENT OCCURS VIA MIXED TYPE 1 AND TYPE 2 PATHWAYS AND RESULTS IN INACTIVATION SITE-SPECIFIC DAMAGE AND INTRA- AND INTER-MOLECULAR CROSSLINKS Autores: Fuentes-Lemus E.; Mariotti M.; Reyes J.; Leinisch F.; Hgglund P.; Silva E.; Davies M.J.; Lpez-Alarcn C. Año: 2020 Link: https://doi.org/10.1016/j.freeradbiomed.2020.03.004
• FORMATION AND CHARACTERIZATION OF CROSSLINKS INCLUDING TYR-TRP SPECIES ON ONE ELECTRON OXIDATION OF FREE TYR AND TRP RESIDUES BY CARBONATE RADICAL ANION Autores: David Figueroa; Juan; Maria Zarate; Ana; Fuentes-Lemus; Eduardo; Davies; Michael J.; Lopez-Alarcon; Camilo Año: 2020
• FREE RADICALS DERIVED FROM ?-RADIOLYSIS OF WATER AND AAPH THERMOLYSIS MEDIATE OXIDATIVE CROSSLINKING OF EGFP INVOLVING TYR-TYR AND TYR-CYS BONDS: THE FLUORESCENCE OF THE PROTEIN IS CONSERVED ONLY TOWARDS PEROXYL RADICALS Autores: Zamora R.A.; Fuentes-Lemus E.; Barrias P.; Herrera-Morande A.; Mura F.; Guix V.; Castro-Fernandez V.; Rojas; T; Lpez-Alarcn C.; Aguirre P.; Rivas-Aravena A.; Aspe A. Año: 2020 Link: https://doi.org/10.1016/j.freeradbiomed.2020.02.006
• PROTEIN QUANTIFICATION BY BICINCHONINIC ACID BCA ASSAY FOLLOWS COMPLEX KINETICS AND CAN BE PERFORMED AT SHORT INCUBATION TIMES Autores: Cortes-Rios; Javiera; Maria Zarate; Ana; David Figueroa; Juan; Medina; Joaquin; Fuentes-Lemus; Eduardo; Rodriguez-Fernandez; Maria; Aliaga; Margarita; Lopez-Alarcon; Camilo Año: 2020 Link: https://doi.org/10.1016/j.ab.2020.113904